The South Toe River is a river in Yancey County in Western North Carolina. The name Toe is taken from its original name Estatoe, pronounced 'S - ta - toe', a native American name associated with the Estatoe trade route leading down from the NC mountains through Brevard where there is a historical plaque with information that affirms the route, on into South Carolina where a village of the same name was located.

Yancey County is a county located in the U.S. state of North Carolina. As of the 2020 census, the population was 18,470. Its county seat is Burnsville.