Southampton is a town in Hampshire County, Massachusetts, United States. It was established first as a district of Northampton in 1732. It was incorporated in 1775. The name Southampton was given to it during its first town meeting in 1773. Its ZIP code is 01073. Southampton is part of the Springfield, Massachusetts Metropolitan Statistical Area. The town had a population of 6,224 at the 2020 census.

Hampshire County is a historical and judicial county located in the U.S. state of Massachusetts. As of the 2020 census, the population was 162,308. Its most populous municipality is Amherst, its largest town in terms of landmass is Belchertown, and its traditional county seat is Northampton. The county is named after the county Hampshire, in England. Hampshire County is part of the Springfield, MA Metropolitan Statistical Area. Together with Hampden County, Hampshire County municipalities belong to the Pioneer Valley Planning Commission.