Southeast Missouri State University is a public university in Cape Girardeau, Missouri. In addition to the main campus, the university has four regional campuses offering full degree programs and a secondary campus housing the Holland College of Arts and Media. The university is accredited by the Higher Learning Commission.

Cape Girardeau is a city in Cape Girardeau and Scott Counties in the U.S. state of Missouri. At the 2020 census, the population was 39,540. The city is one of two principal cities of the Cape Girardeau, MO-IL Metropolitan Statistical Area, which encompasses Alexander County, Illinois, Bollinger County, Missouri and Cape Girardeau County, Missouri and has a population of 97,517. The sliver of the city located in Scott County is part of the Sikeston Micropolitan Statistical Area, and the entire city forms the core of the Cape Girardeau-Sikeston Combined Statistical Area.