Southern California is a geographic and cultural region that generally comprises the southern portion of the U.S. state of California. It includes the Los Angeles metropolitan area as well as the Inland Empire. The region generally contains ten of California's 58 counties: Imperial, Kern, Los Angeles, Orange, Riverside, San Bernardino, San Diego, Santa Barbara, San Luis Obispo and Ventura counties.

Greater Los Angeles is the most populous metropolitan area in the U.S. state of California, encompassing five counties in Southern California extending from Ventura County in the west to San Bernardino County and Riverside County in the east, with Los Angeles County in the center, and Orange County to the southeast. The Los Angeles–Anaheim–Riverside combined statistical area (CSA) covers 33,954 square miles (87,940 km2), making it the largest metropolitan region in the United States by land area. The contiguous urban area is 2,281 square miles (5,910 km2), whereas the remainder mostly consists of mountain and desert areas. With a population of 18.4 million in 2024, it is the second-largest metropolitan area in the country, behind New York, as well as one of the largest megacities in the world.