Southern California Institute of Architecture (SCI-Arc) is a private architecture school in Los Angeles, California. Founded in 1972, SCI-Arc was initially regarded as both institutionally and artistically avant-garde and more adventurous than traditional architecture schools based in the United States. It consists of approximately 500 students and 80 faculty members, some of whom are practicing architects. It is based in the quarter-mile long (0.40 km) former Santa Fe Freight Depot in the Arts District in downtown Los Angeles and also offers community events such as outreach programs, free exhibitions, and public lectures.

Santa Fe Freight Depot is a quarter-mile-long building in the industrial area to the east of Downtown Los Angeles, now known as the Arts District. The Southern California Institute of Architecture converted the structure into its campus in 2000. The building's use as a school has helped revitalize a neighborhood previously considered "a gritty corner of downtown".