Southern Indiana is a geographic and cultural region that generally comprises the southern third of the U.S. state of Indiana and borders the states of Illinois to the west, Kentucky to the south, and Ohio to the east. Spanning the state's southernmost 33 counties, its main population centers include Southwestern Indiana, the Louisville metropolitan area (south), and the Cincinnati metropolitan area (southeast). The region's history and geography have led to a blending of Northern and Southern cultures, distinct from the rest of the state. It is often considered to be part of the Upland South and lower Midwest.

Evansville is a city in and the county seat of Vanderburgh County, Indiana, United States. With a population of 118,414 at the 2020 census, it is Indiana's third-most populous city after Indianapolis and Fort Wayne, the most populous city in Southern Indiana, and the 249th-most populous city in the United States. It is the central city of the Evansville metropolitan area, a hub of commercial, medical, and cultural activity of southwestern Indiana and the Illinois–Indiana–Kentucky tri-state area, which is home to over 911,000 people. The 38th parallel north crosses the north side of the city and is marked on Interstate 69 immediately north of its junction with Indiana 62 within the city's east side.