The Southern Red Sea Region, is an administrative region of Eritrea. It lies along the southern half of the Red Sea, and contains the coastal city of Assab. It borders the Northern Red Sea Region, and has an area of around 27,600 km2 (10,700 sq mi).

The regions of Eritrea are the primary geographical divisions through which Eritrea is administered. Six in total, they include the Central, Anseba, Gash-Barka, Southern, Northern Red Sea and Southern Red Sea regions.