In peak bagging terminology in the United States, the Southern Sixers refers to the group of mountains in the southern states of North Carolina and Tennessee with elevations above sea level of at least six thousand feet. The southern sixers are the tallest group of mountains in the eastern United States and the only peaks in the Appalachian Mountains besides New Hampshire's Mount Washington to exceed 6,000 feet.

Great Smoky Mountains National Park is an American national park in the southeastern United States, with parts in North Carolina and Tennessee. The park straddles the ridgeline of the Great Smoky Mountains, part of the Blue Ridge Mountains, which are a division of the larger Appalachian Mountain chain. The park contains some of the highest mountains in eastern North America, including Clingmans Dome, Mount Guyot, and Mount Le Conte. The border between the two states runs northeast to southwest through the center of the park. The Appalachian Trail passes through the center of the park on its route from Georgia to Maine. With 13 million visitors in 2023, the Great Smoky Mountains National Park is the most visited national park in the United States.