In boxing and some other sports, a southpaw stance is where the boxer has the right hand and the right foot forward, leading with right jabs, and following with a left cross right hook. It is the normal stance for a left-handed boxer. The corresponding boxing designation for a right-handed boxer is the orthodox stance, which is generally a mirror-image of the southpaw stance. In American English, "southpaw" generally refers to a person who is left-handed.

In combat sports such as boxing and MMA, an orthodox stance, also known as a northpaw stance, is one in which the fighter places their left foot in front, thus placing their left side closer to the opponent. Because it places the right side in the rear, the orthodox stance can allow for more rotation and distance to accelerate right sided strikes, in turn generating more power. This makes it the most common stance in boxing, as well as MMA, and primarily used by right-handed fighters.