The Southwest Inn fire in Houston, Texas on May 31, 2013 was a fire in an Indian restaurant that spread to an adjoining hotel. The fire claimed the biggest casualty loss for the Houston Fire Department since its inception. Four firefighters were killed and 13 others were injured that day while fighting the five-alarm fire at the Southwest Inn located in Southwest Houston. On March 7, 2017, Captain Bill Dowling, who lost both his legs battling the fire in 2013, died of complications from his line-of-duty injuries.

Southwest Houston is a region in Houston, Texas, United States. The area is considered to be from Texas State Highway 6, south of Westpark Tollway to north of U.S. Route 90.