Soyuz MS-18 was a Soyuz spaceflight that was launched on 9 April 2021 at 07:42:41 UTC. It transported three members of the Expedition 64 crew to the International Space Station (ISS). Soyuz MS-18 was the 146th crewed flight of a Soyuz spacecraft. The launching crew consisted of a Russian commander, a Russian flight engineer, and an American flight engineer of NASA. The spacecraft returned to Earth on 17 October 2021 following 191 days in space. The flight served as the landing vehicle for the Russian film director Klim Shipenko and actress Yulia Peresild who launched to the ISS aboard Soyuz MS-19 and spent twelve days in space in order to film a movie, Vyzov.

Expedition 64 was the 64th long-duration expedition to the International Space Station (ISS) that began on 21 October 2020 with the undocking and departure of Soyuz MS-16. The expedition started with the three crew members who launched onboard Soyuz MS-17 and reached its full complement with the arrival of SpaceX Crew-1, the first operational flight of NASA's Commercial Crew Program (CCP). As Crew-1 consists of a crew of four instead of three like the Soyuz, Expedition 64 marks the beginning of operations for crews of seven on the ISS. In the final week of the mission, Soyuz MS-18 and its three person crew joined the mission. The expedition ended on 17 April 2021 with the departure of Soyuz MS-17.