Soyuz TMA-10 was a human spaceflight mission using a Soyuz-TMA spacecraft to transport personnel to and from the International Space Station (ISS). The mission began at 17:31:09 UTC on April 7, 2007 when the spacecraft was launched from the Baikonur Cosmodrome by a Soyuz FG launch vehicle. Soyuz TMA-10 brought to the station two members of ISS Expedition 15 crew, along with one spaceflight participant. It remained at the space station as an escape craft until it was replaced by Soyuz TMA-11 in October 2007.

The Soyuz-FG launch vehicle was an improved version of the Soyuz-U from the R-7 family of rockets, designed and constructed by TsSKB-Progress in Samara, Russia. Guidance, navigation, and control system was developed and manufactured by "Polisvit" Special Design Bureau.