Soyuz TMA-16M was a 2015 flight to the International Space Station. It transported three members of the Expedition 43 crew to the station. TMA-16M was the 125th flight of a Soyuz spacecraft, the first having launched in 1967.

Expedition 43 was the 43rd expedition to the International Space Station. It commenced on 11 March 2015 with the undocking of Soyuz TMA-14M, returning the crew of Expedition 42 to Earth and ended with the departure of Soyuz TMA-15M on 11 June 2015.