Soyuz TMA-18 was a 2010 Soyuz flight to the International Space Station (ISS). TMA-18 was the 105th crewed flight of a Soyuz spacecraft since the first crewed flight in 1967.

Poisk, also known as the Mini-Research Module 2, Малый исследовательский модуль 2, or МИМ 2, is a docking module of the International Space Station. Its original name was Docking Module 2, as it is almost identical to the Pirs Docking Compartment. Added in 2009, Poisk was the first major Russian addition to the International Space Station since 2001. Poisk is overall the same design as the docking module Pirs. Whereas Pirs was attached to the nadir ("bottom") port of Zvezda, Poisk is attached to the zenith ("top"); Pirs was closer to the Earth with the ISS in its usual orientation, and Poisk is on the other side. Poisk is Russian for explore or search. Poisk combines various docking, EVA, and science capabilities. It has two egress hatches for EVAs in addition to the two spacecraft docking ports. Although Poisk is designated as Mini-Research Module 2, it arrived before Mini-Research Module 1 (Rassvet), which had a different design; Poisk looks more like the Pirs docking port, which is not designated as a mini-research module.