SpaceX CRS-10, also known as SpX-10, was a Dragon Commercial Resupply Service mission to the International Space Station (ISS) which launched on 19 February 2017. The mission was contracted by NASA as part of its Commercial Resupply Services program and was launched by SpaceX aboard the 30th flight of the Falcon 9 rocket. The mission ended on 19 March 2017 when the Dragon spacecraft left the ISS and safely returned to Earth.

Commercial Resupply Services (CRS) are a series of flights awarded by NASA for the delivery of cargo and supplies to the International Space Station (ISS) on commercially operated spacecraft. The first CRS contracts were signed in 2008 and awarded $1.6 billion to SpaceX for twelve cargo Dragon and $1.9 billion to Orbital Sciences for eight Cygnus flights, covering deliveries to 2016. The Falcon 9 and Antares rockets were also developed under the CRS program to deliver cargo spacecraft to the ISS.