SpaceX Crew-1 was the first operational crewed flight of a Crew Dragon spacecraft, and the maiden flight of the Crew Dragon Resilience spacecraft. It was also the second crewed orbital flight launch by the United States since that of STS-135 in July 2011. Resilience launched on 16 November 2020 at 00:27:17 UTC on a Falcon 9 from Kennedy Space Center Launch Complex 39A (LC-39A), carrying NASA astronauts Michael Hopkins, Victor Glover and Shannon Walker along with JAXA astronaut Soichi Noguchi, all members of the Expedition 64 crew. The mission was the second overall crewed orbital flight of the Crew Dragon.

Falcon 9 is a partially reusable medium-lift launch vehicle that can carry cargo and crew into Earth orbit, designed, manufactured and launched by American aerospace company SpaceX. It can also be used as an expendable heavy-lift launch vehicle. The first Falcon 9 launch was on 4 June 2010. The first Falcon 9 commercial resupply mission to the International Space Station (ISS) launched on 8 October 2012. In 2020 it became the first commercial rocket to launch humans to orbit and remains the only such vehicle. It is the only U.S. rocket certified for transporting humans to the ISS. In 2022, it became the U.S. rocket with the most launches in history and with the best safety record, having suffered just one flight failure.