SpaceX Crew-1 was the first operational crewed flight of a Crew Dragon spacecraft, and the maiden flight of the Crew Dragon Resilience spacecraft. It was also the second crewed orbital flight launch by the United States since that of STS-135 in July 2011. Resilience launched on 16 November 2020 at 00:27:17 UTC on a Falcon 9 from Kennedy Space Center Launch Complex 39A (LC-39A), carrying NASA astronauts Michael Hopkins, Victor Glover and Shannon Walker along with JAXA astronaut Soichi Noguchi, all members of the Expedition 64 crew. The mission was the second overall crewed orbital flight of the Crew Dragon.

Dragon 2 is a class of partially reusable spacecraft developed, manufactured, and operated by American space company SpaceX, primarily for flights to the International Space Station (ISS). SpaceX also launches private missions, such as Inspiration4 and Axiom Space Missions. There are two variants of the Dragon spacecraft: Crew Dragon, a spacecraft capable of ferrying four crewmembers, and Cargo Dragon, a replacement for the original Dragon 1 used to carry freight to and from space. The spacecraft consists of a reusable space capsule and an expendable trunk module. The spacecraft launches atop a Falcon 9 Block 5 rocket and the capsule returns to Earth through splashdown. It has proven to be the most cost effective spacecraft in history to be used by NASA.