SpaceX Crew-5 was the fifth operational NASA Commercial Crew Program flight of a Crew Dragon spacecraft, and the eighth overall crewed orbital flight. The mission was successfully launched on 5 October 2022 with the aim of transporting four crew members to the International Space Station (ISS). The Crew Dragon spacecraft docked at the ISS on 6 October 2022 at 21:01 UTC.

The Commercial Crew Program (CCP) provides commercially operated crew transportation service to and from the International Space Station (ISS) under contract to NASA, conducting crew rotations between the expeditions of the International Space Station program. American space manufacturer SpaceX began providing service in 2020, using the Crew Dragon spacecraft, and NASA plans to add Boeing when its Boeing Starliner spacecraft becomes operational no earlier than 2025. NASA has contracted for six operational missions from Boeing and fourteen from SpaceX, ensuring sufficient support for ISS through 2030.