SpaceX Crew-6 was the sixth crewed operational NASA Commercial Crew flight of a Crew Dragon spacecraft, and the ninth overall crewed orbital flight. The mission launched on 2 March 2023 at 05:34:14 UTC, and it successfully docked to the International Space Station (ISS) on 3 March 2023 at 06:40 UTC. The Crew-6 mission transported four crew members to the International Space Station (ISS). Two NASA astronauts, a United Arab Emirates astronaut, and a Russian cosmonaut were assigned to the mission. The two NASA astronauts are Stephen Bowen and Warren Hoburg. The cosmonaut, Andrey Fedyaev, was reassigned from Soyuz MS-23. Sultan Al Neyadi was the commander of the United Arab Emirates' mission on the flight.

The Commercial Crew Program (CCP) provides commercially operated crew transportation service to and from the International Space Station (ISS) under contract to NASA, conducting crew rotations between the expeditions of the International Space Station program. American space manufacturer SpaceX began providing service in 2020, using the Crew Dragon spacecraft, and NASA plans to add Boeing when its Boeing Starliner spacecraft becomes operational no earlier than 2025. NASA has contracted for six operational missions from Boeing and fourteen from SpaceX, ensuring sufficient support for ISS through 2030.