The first Space Mouse is a comic book character published from 1953 to around 1956 by Avon Publications. Space Mouse is also the name of a 1959 Universal Studios cartoon featuring two mice and a cat named Hickory, Dickory, and Doc. A second Space Mouse character was published by Dell Comics from 1960 to around 1965. The Dell Comics version was also featured in a 1960 cartoon produced by Walter Lantz, entitled The Secret Weapon.

Walter Benjamin Lantz was an American cartoonist, animator, producer and director best known for founding Walter Lantz Productions and creating Woody Woodpecker.