Space Shuttle Endeavour is a retired orbiter from NASA's Space Shuttle program and the fifth and final operational Shuttle built. It embarked on its first mission, STS-49, in May 1992 and its 25th and final mission, STS-134, in May 2011. STS-134 was expected to be the final mission of the Space Shuttle program, but with the authorization of STS-135 by the United States Congress, Atlantis became the last shuttle to fly.

The Space Shuttle orbiter is the spaceplane component of the Space Shuttle, a partially reusable orbital spacecraft system that was part of the discontinued Space Shuttle program. Operated from 1977 to 2011 by NASA, the U.S. space agency, this vehicle could carry astronauts and payloads into low Earth orbit, perform in-space operations, then re-enter the atmosphere and land as a glider, returning its crew and any on-board payload to the Earth.