Spaceflight is an application of astronautics to fly objects, usually spacecraft, into or through outer space, either with or without humans on board. Most spaceflight is uncrewed and conducted mainly with spacecraft such as satellites in orbit around Earth, but also includes space probes for flights beyond Earth orbit. Such spaceflight operate either by telerobotic or autonomous control. The more complex human spaceflight has been pursued soon after the first orbital satellites and has reached the Moon and permanent human presence in space around Earth, particularly with the use of space stations. Human spaceflight programs include the Soyuz, Shenzhou, the past Apollo Moon landing and the Space Shuttle programs. Other current spaceflight are conducted to the International Space Station and to China's Tiangong Space Station.

Humans have been present in space either, in the common sense, through their direct presence and activity like human spaceflight, or through mediation of their presence and activity like with uncrewed spaceflight, making "telepresence" possible. Human presence in space, particularly through mediation, can take many physical forms from space debris, uncrewed spacecraft, artificial satellites, space observatories, crewed spacecraft, art in space, to human outposts in outer space such as space stations. While human presence in space, particularly its continuation and permanence can be a goal in itself, human presence can have a range of purposes and modes from space exploration, commercial use of space to extraterrestrial settlement or even space colonization and militarisation of space. Human presence in space is realized and sustained through the advancement and application of space sciences, particularly astronautics in the form of spaceflight and space infrastructure.