The Spanish conquest of Nicaragua was the campaign undertaken by the Spanish conquistadores against the natives of the territory now incorporated into the modern Central American republic of Nicaragua during the colonisation of the Americas. Before European contact in the early 16th century, Nicaragua was inhabited by a number of indigenous peoples. In the west, these included Mesoamerican groups such as the Chorotega, the Nicarao, and the Subtiaba. Other groups included the Matagalpa and the Tacacho.

The Nicarao are a Nahua people who live in western Nicaragua and northwestern Costa Rica. They spoke the Nahuat language before it went extinct in both countries.