Several special routes of U.S. Route 221 exist. In order from south to north they are as follows.
Overlapping US 221, 321, and 421 Truck routes along NC 105, in Boone
US 221 Bus. southbound at US 221 and SR 122 in Bedford
U.S. Route 221
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U.S. Route 221 is a 734-mile-long spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business. It travels through the states of Flor
Special routes of U.S. Route 221
…Several special routes of U.S. Route 221 exist. In order from south to north they are as follows. U.S. Route 221 Truck (US 221 Truck) directs truck drivers, that are passing through, to follow…
View north along US 221 at SR 615 just north of Floyd, Virginia