Special routes of U.S. Route 421
Several special routes of U.S. Route 421 exist. In order from south to north they are as follows.
South Front Street looking south as it passes by the Wilmington Terminal tank farm.
US 23 Bus./US 58 Bus./US 421 Bus. in Gate City
U.S. Route 421 is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee, Virginia, Kentucky, and Indiana. The highway runs for 941 miles (1,514 km) from Fort Fisher, North Carolina, to US 20 in Michigan City, Indiana. Along its routing, US 421 serves several cities including Wilmington, North Carolina; Greensboro, North Carolina; Bristol, Tennessee and Virginia; Lexington, Kentucky; and Indianapolis, Indiana. US 421 is a spur route of US 21, which it meets west of Yadkinville, North Carolina.
US 421 south near the Red White and Blue Road (exit 276) in eastern Wilkes County, July 2007
US 421 near Bristol in June 2006
US 421 in Michigan City, just north of I-94
Beginning of US 421 near Fort Fisher State Recreation Area