Spennithorne is a village and civil parish in lower Wensleydale in North Yorkshire, England. The village is situated 2 miles (3.2 km) south-east of the market town Leyburn, on a slight elevation above the River Ure, which forms the southern boundary of the parish. The village is overlooked by the steeple of St Michael and All Angels Church.

The River Ure in North Yorkshire, England, is about 74 miles (119 km) long from its source to the point where it becomes the River Ouse. It is the principal river of Wensleydale, which is the only major dale now named after a village rather than its river. The old name for the valley was Yoredale after the river that runs through it.