Spider-Man: Friend or Foe is a 2007 action-adventure beat 'em up platform game, based on the Marvel Comics character Spider-Man. The game borrows characters and designs from Sam Raimi's Spider-Man trilogy, with a plot that is non-canon to the films and therefore taking place within a divergent timeline where the villains seen in the films managed to survive. It features two player co-op gameplay, where one player controls Spider-Man and another one of his allies. The storyline of the game revolves around P.H.A.N.T.O.M.s, dangerous creatures created by mixing symbiotes with holographic technology, which a mysterious villain plans to use to take over the world. This villain has also captured and brainwashed many of Spider-Man's foes to help him acquire meteor shards that will strengthen his army. After being recruited by S.H.I.E.L.D., Spider-Man journeys across the globe to retrieve these shards himself and recruit more allies to his cause.

Peter Benjamin Parker, also known by his alter ego Spider-Man, is a fictional superhero portrayed by Tobey Maguire that is based on the comic book character of the same name. He is the protagonist of Sam Raimi's Spider-Man film in 2002, its two sequels, and in tie-in video games. This version of the character was followed by Andrew Garfield's portrayal in Marc Webb's The Amazing Spider-Man duology (2012–2014), with a further iteration being portrayed by Tom Holland set within the Marvel Cinematic Universe (MCU) (2016–present). Maguire reprised his role as a supporting character in the MCU film Spider-Man: No Way Home (2021), appearing as an older version of himself alongside his two successors' versions of the character. To distinguish himself from the two other versions of himself, he is nicknamed "Peter-Two" by them, referred to by Marvel's official website as the Friendly Neighborhood Spider-Man, and in the film's script as "Raimi-Verse Peter" and "Raimi-Verse Spider-Man".