Spiro Theodore Agnew was the 39th vice president of the United States, serving from 1969 until his resignation in 1973. He is the second of two vice presidents to resign the position, the first being John C. Calhoun in 1832.

John Caldwell Calhoun was an American statesman and political theorist who served as the seventh vice president of the United States from 1825 to 1832. Born in South Carolina, he adamantly defended American slavery and sought to protect the interests of white Southerners. Calhoun began his political career as a nationalist, modernizer and proponent of a strong federal government and protective tariffs. In the late 1820s, his views changed radically, and he became a leading proponent of states' rights, limited government, nullification, and opposition to high tariffs. Calhoun saw Northern acceptance of those policies as a condition of the South's remaining in the Union. His beliefs heavily influenced the South's secession from the Union in 1860 and 1861. He was the first of two vice presidents to resign from the position, the second being Spiro Agnew, who resigned in 1973.