Spy Smasher is a 12-episode 1942 Republic serial film based on the Fawcett Comics character Spy Smasher which is now a part of DC Comics. It was the 25th of the 66 serials produced by Republic. The serial was directed by William Witney with Kane Richmond and Marguerite Chapman as the leads. The serial was Chapman's big break into a career in film and television. Spy Smasher is a very highly regarded serial. In 1966, a television film was made from the serial footage under the title Spy Smasher Returns.

Marguerite Chapman was an American film and television actress.