Tisquantum, more commonly known as Squanto, was a member of the Wampanoag Patuxet tribe best known for being an early liaison between the Native American population in Southern New England and the Mayflower Pilgrims who made their settlement at the site of Tisquantum's former summer village, now Plymouth, Massachusetts. The Patuxet tribe had lived on the western coast of Cape Cod Bay, but an epidemic infection wiped them out, likely brought by previous European explorers.

The Pilgrims, also known as the Pilgrim Fathers, were the English settlers who traveled to America on the Mayflower and established the Plymouth Colony in Plymouth, Massachusetts. The Pilgrims' leadership came from the religious congregations of Brownists, or Separatists, who had fled religious persecution in England for the tolerance of 17th-century Holland in the Netherlands.