St. Agatha–St. James Church is a Roman Catholic church in Philadelphia, Pennsylvania, established in 1850. As the first Roman Catholic parish in Philadelphia west of the Schuylkil River, St. Agatha-St. James Church is the mother church of West Philadelphia. Originally, a small church dedicated to St James the Greater was constructed in an open field at 38th and Chestnut Streets, but with the rapid influx of Catholics into the area, particularly from Ireland, the decision was made to build a larger church on the same land. Construction of the current building, designed by Philadelphia architect Edwin Forrest Durang, began on October 16, 1881 and was completed on the same day in 1887. The hand-carved wooden confessionals from the original 1850 church were placed in the new building and remain to this day.

Edwin Forrest Durang was an American architect. He kept offices in Philadelphia and specialized in ecclesiastical and theatrical design.