St. Andrew's College is an Anglican high school for boys located in Makhanda (Grahamstown), Eastern Cape province of South Africa. It was founded in 1855 by the Right Reverend John Armstrong, the first Bishop of Grahamstown. It is a semi boarding school, with a number of day boys. St. Andrew's College caters to 480 pupils from around the globe. The school is also a member of the G30 Schools group and closely associated with its brother school, St. Andrew's Preparatory School, and its sister school the Diocesan School for Girls.

Makhanda, formerly known as Grahamstown, is a town of about 140,000 people in the Eastern Cape province of South Africa. It is situated about 110 kilometres (70 mi) northeast of Gqeberha and 130 kilometres (80 mi) southwest of East London. It is the largest town in the Makana Local Municipality, and the seat of the municipal council. It also hosts Rhodes University, the Eastern Cape Division of the High Court, the South African Library for the Blind (SALB), a diocese of the Anglican Church of Southern Africa, and 6 South African Infantry Battalion. Furthermore, located approximately 3 km south-east of the town lies the world renowned Waterloo Farm, the only estuarine fossil site in the world from 360 million years ago with exceptional soft-tissue preservation.