The Cathedral of St. Catherine is a religious building belonging to the Orthodox faith which is situated within the fortress of Kherson, Ukraine. It was built in 1781–1786, one of the earliest churches in New Russia. It is a domed sandstone structure with a Tuscan portico and heavily rusticated walls. The church was dedicated to Catherine of Alexandria, the patron saint of the reigning empress.

Kherson is a port city in Ukraine that serves as the administrative centre of Kherson Oblast. Located by the Black Sea and on the Dnieper River, Kherson is the home to a major ship-building industry and is a regional economic centre. At the beginning of 2022, its population was estimated at 279,131.