St. Francis Preparatory School, commonly known as St. Francis Prep, is a private, independent Catholic college preparatory school in Fresh Meadows, Queens, New York City, New York. It is the largest non-diocesan Catholic high school in the United States. St. Francis is run by the Franciscan Brothers of Brooklyn, who maintain a residence on the top floor of the school. As of the 2015–16 school year, enrollment at St. Francis was 2,489.

Fresh Meadows is a neighborhood in the northeastern section of the New York City borough of Queens. Fresh Meadows used to be part of the broader town of Flushing and is bordered to the north by the Horace Harding Expressway and Auburndale; to the west by Pomonok, St. John's University, Hillcrest, and Utopia; to the east by Cunningham Park and the Clearview Expressway; and to the south by the Grand Central Parkway.