St. Francis Square is a 1.30-hectare (3.2-acre) mixed-use commercial complex located in Ortigas Center, Mandaluyong, Philippines. Groundbreaking and construction of the complex began in 1998 and was completed in 2000. Due to some controversies regarding the St. Francis Square Group of Companies, construction and the finishing of interiors were halted. Construction resumed in 2009 and the building was finished in 2011.

Ortigas Center is a central business district located within the joint boundaries of Pasig, Mandaluyong and Quezon City, within the Metro Manila region in the Philippines. With an area of more than 100 hectares, it is Metro Manila's second most important business district after the (Makati CBD). It is governed by Ortigas Center Association, Inc.