St. George's Cathedral is an Anglican (Episcopal) cathedral in Sheikh Jarrah, Jerusalem, established in 1899. It became the seat of the Bishop of Jerusalem of the Episcopal Church in Jerusalem and the Middle East, having taken the title from Christ Church, Jerusalem, built 50 years before.

Sheikh Jarrah is a predominantly Palestinian neighborhood in East Jerusalem, two kilometres north of the Old City, on the road to Mount Scopus. It received its name from the 13th-century tomb of Hussam al-Din al-Jarrahi, a physician of Saladin, located within its vicinity. The modern neighborhood was founded in 1865 and gradually became a residential center of Jerusalem's Muslim elite, particularly the al-Husayni family. After the 1948 Arab–Israeli War, it became under Jordanian-held East Jerusalem, bordering the no-man's land area with Israeli-held West Jerusalem until Israel occupied the neighborhood in the 1967 Six-Day War. Most of its present Palestinian population is said to come from refugees expelled from Jerusalem's Talbiya neighbourhood in 1948.