St. John's Regional Medical Center is a hospital located in Oxnard, California in the United States, and is operated by Dignity Health, along with its sister hospital, St. John's Hospital Camarillo in Camarillo. The hospital was founded in 1912.

Dignity Health is a California-based not-for-profit public-benefit corporation that operated hospitals and ancillary care facilities in three states. Dignity Health was the fifth-largest hospital system in the nation and the largest not-for-profit hospital provider in California.