St. Joseph's Healthcare Hamilton is a 777-bed research hospital and academic health science centre located in Hamilton, Ontario, that is affiliated with the Michael G. DeGroote School of Medicine of McMaster University as well as Mohawk College. It is part of the St. Joseph's Health System and serves as the regional kidney transplant centre for a population of approximately 1.2 million people.

An academic medical centre (AMC), variously also known as academic health science centre, academic health science system, or academic health science partnership, is an educational and healthcare institute formed by the grouping of a health professional school with an affiliated teaching hospital or hospital network.