St. Louis City SC is an American professional men's soccer club based in St. Louis, Missouri. City SC competes in Major League Soccer (MLS) as a member of the Western Conference and joined in 2023 as an expansion team. The club was established in 2019 and plays its home matches at CityPark, a new soccer-specific stadium across from Union Station in Downtown West St. Louis.

St. Louis is an independent city in the U.S. state of Missouri. It is located near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a population of 301,578, while its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is the largest metropolitan area in Missouri and the second largest in Illinois. The city's combined statistical area (CSA) is the 20th largest in the United States.