St. Mary's Chapel is a historic Episcopal chapel located at 900 Hillsborough Street in Raleigh, North Carolina, United States. The chapel is on the grounds of St. Mary's School, a college-preparatory boarding and day school founded in the 1840s. The 19th-century building was designed by architect Richard Upjohn in the Gothic Revival style and later expanded. It was added to the National Register of Historic Places (NRHP) in 1970.

Richard Upjohn was a British architect who emigrated to the United States and became most famous for his Gothic Revival churches. He was partially responsible for launching the movement to popularity in the United States. Upjohn also did extensive work in and helped to popularize the Italianate style. He was a founder and the first president of the American Institute of Architects. His son, Richard Michell Upjohn, (1828-1903), was also a well-known architect and served as a partner in his continued architectural firm in New York.