St. Mary's University is a private Roman Catholic university in San Antonio, Texas. Founded by the Society of Mary (Marianists) in 1852, St. Mary's is the oldest Catholic university in Texas and the American Southwest.

San Antonio, officially the City of San Antonio, is a city in the U.S. state of Texas and the most populous city in Greater San Antonio, the third-largest metropolitan area in Texas and the 24th-largest metropolitan area in the United States at 2.6 million people in 2020. It is the most populous city in and seat of Bexar County. The city is the seventh-most populous in the United States, the second-largest in the Southern United States, and the second-most populous in Texas after Houston.