St. Matthews is a city in Jefferson County, Kentucky, United States. It forms part of the Louisville Metro government but is separately incorporated as a home rule-class city. The population was 17,472 at the 2010 census, up from 15,852 at the 2000 census. It is the 23rd-largest city in the state. St. Matthews is one of the state's major shopping areas, home to the fifth-largest mall in Kentucky along with many smaller shopping centers along Shelbyville Road.

Jefferson County is located in the north central portion of the U.S. state of Kentucky. As of the 2020 census, the population was 782,969. It is the most populous county in the commonwealth.