St. Paul Diocesan Junior-Senior High School is a private, Roman Catholic high school in Worcester, Massachusetts, United States, associated with the Roman Catholic Diocese of Worcester. It was established on the site of Holy Name Central Catholic Junior Senior High School.

The Diocese of Worcester is a Latin Church ecclesiastical territory, or diocese, of the Catholic Church in central Massachusetts in the United States. The diocese consists of Worcester County. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of Boston. The patron saint of the diocese is Paul the Apostle.