The Saint Publius Parish Church, also known as the Floriana Parish Church is a Roman Catholic parish church in Floriana, Malta, dedicated to Saint Publius. It was constructed at several stages between the 18th and 20th centuries.

Floriana, also known by its title Borgo Vilhena, is a fortified town in the Port Region area of Malta, just outside the capital city Valletta. It has a population of 2,205 as of March 2014. Floriana is the birthplace of many famous Maltese, amongst which the composer of the national anthem, 'L-Innu Malti', Robert Samut; former Bishop of Malta Dun Mauro Caruana, the poets Oliver Friggieri and Maria Grech Ganado, the writer and politician Herbert Ganado and Swedish Idol winner Kevin Borg.