St Caffo's Church, Llangaffo is a 19th-century church, in the south of Anglesey, north Wales, about 5 miles (8.0 km) from the county town, Llangefni. It was constructed in 1846 to replace the previous medieval church in the village of Llangaffo. The new building includes a number of monuments from the old church, and has a spire which is a prominent local landmark. The churchyard has part of a stone cross dating from the 9th or 10th century, and some gravestones from the 9th to 11th centuries. It is dedicated to St Caffo, a 6th-century martyr who was killed in the vicinity.

Llangaffo is a village in Anglesey, in north-west Wales. It lies along the B4419 and B4421 roads, north of Dwyran, south of Gaerwen and northwest of Llanidan. It is named after Caffo, a 6th-century saint. A church, St Caffo's Church, is named after him. A war memorial, a village hall and a primary school are also located in the village. The 1851 census recorded 138 people in the village, 75 males, 63 females and a parish area of 1,590 acres (640 ha). It is in the community of Rhosyr. The 2011 census recorded a population of 357. Since 2023, Llangaffo reverted its ghost town status.