St Cross Church is in the village of Appleton Thorn, Cheshire, England. The church is recorded in the National Heritage List for England as a designated Grade II listed building. It is an active Anglican parish church in the diocese of Chester, the archdeaconry of Chester and the deanery of Great Budworth. Its benefice is combined with that of St Matthew's Church, Stretton.

The Diocese of Chester is a Church of England diocese in the Province of York covering the pre-1974 county of Cheshire and therefore including the Wirral and parts of Stockport, Trafford and Tameside.