St Helen's Basilica is an 18th-century Roman Catholic church situated in Birkirkara, Malta. It is built on the baroque design by Salvu Borg and built by Mason Domenico Cachia. The design was inspired, and is similar, to the Mdina Cathedral by Lorenzo Gafa. It was built to replace the role of the main old Parish Church of St. Mary that was damaged in the 1856 earthquake. It eventually became the Collegiate Church and then a Minor Basilica. The current parish archpriest is Mons Louis Suban.

Birkirkara is a city in the eastern region of Malta. It is the second most populous on the island, with 24,356 inhabitants as of 2020. The town consists of five autonomous parishes: Saint Helen, Saint Joseph the Worker, Our Lady of Mount Carmel, Saint Mary and San Gorg Preca. The city's motto is In hoc signo vinces, and its coat of arms is a plain red cross, surmounted by a crown.