St James' Church Paddington, also known as St James' Church Sussex Gardens, is a Church of England parish church in Paddington, London, in the United Kingdom. It is the parish church of Paddington. It is located at the western end of Sussex Gardens, a long tree-lined avenue, about 175 metres (0.109 mi) north of Hyde Park.

Paddington is an area in the City of Westminster, in central London, England. A medieval parish then a metropolitan borough, it was integrated with Westminster and Greater London in 1965. Paddington station, designed by the engineer Isambard Kingdom Brunel opened in 1847. It is also the site of St Mary's Hospital and the former Paddington Green Police Station.