St Luke's is an area in London, England and is located in the London Borough of Islington. It lies just north of the border with the City of London near the Barbican Estate, and the Clerkenwell and Shoreditch areas.

The London Borough of Islington is a London borough which forms part of Inner London, England. Islington has an estimated population of 215,667. It was formed in 1965, under the London Government Act 1963, by the amalgamation of the metropolitan boroughs of Islington and Finsbury.