St Margaret's Church is in Main Street, Hornby, Lancashire, England. The church is recorded in the National Heritage List for England as a designated Grade I listed building. It is an active Anglican parish church in the diocese of Blackburn, the archdeaconry of Lancaster and the deanery of Tunstall. Its benefice is combined with those of St Michael, Whittington, St John, Arkholme, and St John, Gressingham.

Hornby is a village and former civil parish located 9 miles (14 km) from Lancaster, now part of the parish of Hornby-with-Farleton, within the Lancaster district of the county of Lancashire, England. Situated on the A683 the village lies at the confluence of the River Wenning and Lune In 2011 the built up area had a population of 468. In 1881, the parish had a population of 358.