St Mary's Church is the Church of England parish church of Pyrton, Oxfordshire, England. Its parish is part of the benefice of Icknield, in the deanery of Aston and Cuddesdon, the archdeaconry of Oxford and the diocese of Oxford. The church is recorded in the National Heritage List for England as a designated Grade II* listed building.

The Diocese of Oxford is a Church of England diocese that forms part of the Province of Canterbury. The diocese is led by the Bishop of Oxford, and the bishop's seat is at Christ Church Cathedral, Oxford. It contains more church buildings than any other diocese and has more paid clergy than any other except London.